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Mutagenicity in Salmonella typhimurium of some angelicin derivatives proposed as new monofunctional agents for the photochemotherapy of psoriasis.

Authors
  • Venturini, S
  • Tamaro, M
  • Monti-Bragadin, C
  • Carlassare, F
Type
Published Article
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Publisher
Elsevier
Publication Date
Jan 01, 1981
Volume
88
Issue
1
Pages
17–22
Identifiers
PMID: 7010144
Source
Medline
License
Unknown

Abstract

A series of angelicin derivatives were tested for their mutagenic activity with and without near-ultraviolet irradiation (NUV) in Salmonella typhimurium strains. After irradiation with NUV, the tested compounds induced different numbers of revertants in strain TA100, indicating that the mutational events involved are base substitutions. In the dark, 3 chemicals behaved as frame-shift mutagens causing reversion in strain TA98.

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