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Mutagenicity of chamuvaritin: a benzyldihydrochalcone isolated from a medicinal plant.

Authors
  • Uwaifo, A O
  • Okorie, D A
  • Bababunmi, E A
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Nov 01, 1979
Volume
8
Issue
1
Pages
87–92
Identifiers
PMID: 228850
Source
Medline
License
Unknown

Abstract

The mutagenic effects of chamuvaritin, dihydrobenzylchalcone isolated from Uvaria chamae, were investigated using Salmonella typhimurium tester strains TA92, TA94--98, TA100--1535, TA1537 and TA1538. The phytochemical was mutagenic in tester strains TA98 and TA100 and required activation by the hepatic S-9 microsomal enzyme preparation.

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