The mouse spot test was used to investigate the in vivo mutagenicity of caprolactam. Among offspring treated with 500 mg/kg, the frequency of spots was increased over controls in 4 separate experiments, leading to the conclusion that caprolactam is mutagenic in the spot test.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/2811928