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Mutagenic activity of tetryl, a nitroaromatic explosive, in three microbial test systems.

Authors
  • Whong, W Z
  • Speciner, N D
  • Edwards, G S
Type
Published Article
Journal
Toxicology Letters
Publisher
Elsevier
Publication Date
Jan 01, 1980
Volume
5
Issue
1
Pages
11–17
Identifiers
PMID: 6445609
Source
Medline
License
Unknown

Abstract

The military explosive N-methyl-N,2,4,6-tetranitroaniline (tetryl) is a direct acting mutagen in three microbial mutagenicity test systems at concentrations as low as 5 microgram/ml. In two of these systems (Neurospora crassa and Salmonella typhimurium) it caused base-pair substitution reversions. In the third (Saccharomyces cerevisiae D4) it caused mitotic gene conversions at two loci. Three nonaromatic explosives (PETN, RDX, HMX) did not exhibit mutagenic activity in the Ames Salmonella test. Further studies on tetryl seem indicated, as past and present human exposure may entail a health risk.

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