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Mussel-Inspired Biocoating for Improving the Adhesion of Dental Pulp Stem Cells in Dental Pulp Regeneration.

Authors
  • Liu, Yanan1, 2, 3, 4
  • Qiu, Ying2
  • Ni, Shilei3
  • Zhang, Xuewei1
  • Sun, Hongchen3
  • Song, Wenlong1
  • Li, Xiangwei2
  • 1 State Key Lab of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130023, P. R. China. , (China)
  • 2 Department of Endodontics, School of Stomatology, Jilin University, Changchun, 130021, P. R. China. , (China)
  • 3 Department of Pathology, School of Stomatology, Jilin University, Changchun, 130021, P. R. China. , (China)
  • 4 ENT Department, Baoding No. 1 Central Hospital, Baoding, 071000, P. R. China. , (China)
Type
Published Article
Journal
Macromolecular rapid communications
Publication Date
Dec 01, 2020
Volume
41
Issue
24
Identifiers
DOI: 10.1002/marc.202000102
PMID: 32483838
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Dental pulp engineering possesses a promising perspective to replacing lost pulp in the root canal and restoring its functions. Stable adhesion of dental pulp stem cells (DPSCs) on the root canal dentin wall is a key element required for reconstruction of a functional odontoblast layer in dental pulp regeneration. To address this challenge, dopamine-modified hyaluronic acid (DA-HA) is coated on dentin to obtain a stable adhesion of DPSCs. The dopamine segment provides adhesion ability to the coating, and the hyaluronic acid increases the biocompatibility. The results show that DPSCs can adhere on the DA-HA coated dentin slice better than those without coating. Simultaneously, DPSCs proliferation can be further promoted on the prepared coating. Therefore, the DA-HA coating may provide a possible way to immobilize odontoblast cell onto dentin surface for pulp regeneration. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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