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Muscle-specific carbonic anhydrase III is a more sensitive marker of muscle damage than creatine kinase in neuromuscular disorders.

Authors
  • Väänänen, H K
  • Takala, T E
  • Tolonen, U
  • Vuori, J
  • Myllylä, V V
Type
Published Article
Journal
Archives of Neurology
Publisher
American Medical Association
Publication Date
Nov 01, 1988
Volume
45
Issue
11
Pages
1254–1256
Identifiers
PMID: 3142447
Source
Medline
License
Unknown

Abstract

Serum concentration of carbonic anhydrase III (S-CA III), a novel marker of type I skeletal muscle cells was measured in 37 patients with neuromuscular diseases (polymyositis, muscular dystrophies, amyotrophic lateral sclerosis, and other neurogenic diseases) and in 24 control patients. Significant elevation in S-CA III was observed in all patient groups. Serum concentration of carbonic anhydrase III correlated positively with serum-creatine kinase. Serum concentration of carbonic anhydrase III was observed to be a more sensitive skeletal muscle marker both in myogenic and in neurogenic muscle affecting diseases than serum creatine kinase.

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