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Muscle proteolysis induced by neural colchicine cuffs cast in situ.

Authors
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Volume
20
Issue
1
Pages
183–186
Identifiers
PMID: 663400
Source
Medline
License
Unknown

Abstract

The effects of neurotrophic factors on muscle protein degradation in rat leg muscle were studied. In order to inhibit axoplasmic transport and therefore transport of "trophic" factors, the colchicine cuff method of Albuquerque et. al. (1972) was modified so that the cuffs were cast in situ. Protein degradation was estimated by monitoring the release of tyrosine from the muscle. Our observations that colchicine cuffs increased tyrosine release are consistent with the concept of nerve-muscle trophism.

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