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Muscle mitochondrial oxidative phosphorylation activity, but not content, is altered with abdominal obesity in sedentary men: synergism with changes in insulin sensitivity.

Authors
  • Chanseaume, Emilie1
  • Barquissau, Valentin
  • Salles, Jérôme
  • Aucouturier, Julien
  • Patrac, Véronique
  • Giraudet, Christophe
  • Gryson, Céline
  • Duché, Pascale
  • Boirie, Yves
  • Chardigny, Jean-Michel
  • Morio, Béatrice
  • 1 Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1019, Centre de Recherche en Nutrition Humaine Auvergne, F-63000 Clermont-Ferrand, France. , (France)
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Jun 01, 2010
Volume
95
Issue
6
Pages
2948–2956
Identifiers
DOI: 10.1210/jc.2009-1938
PMID: 20382691
Source
Medline
License
Unknown

Abstract

Abdominal obesity is associated with alterations in intrinsic muscle mitochondrial function but not content. These adaptations mainly result in reduced mitochondrial ATP production rate in response to insulin resistance.

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