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MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.

Authors
  • Uehara, Tsuyoshi
  • Suefuji, Kyoko
  • Jaeger, Tina
  • Mayer, Christoph
  • Park, James T
Type
Published Article
Journal
Journal of bacteriology
Publication Date
Feb 01, 2006
Volume
188
Issue
4
Pages
1660–1662
Identifiers
PMID: 16452451
Source
Medline
License
Unknown

Abstract

MurQ is an N-acetylmuramic acid-phosphate (MurNAc-P) etherase that converts MurNAc-P to N-acetylglucosamine-phosphate and is essential for growth on MurNAc as the sole source of carbon (T. Jaegar, M. Arsic, and C. Mayer, J. Biol. Chem. 280:30100-30106, 2005). Here we show that MurQ is the only MurNAc-P etherase in Escherichia coli and that MurQ and AnmK kinase are required for utilization of anhydro-MurNAc derived either from cell wall murein or imported from the medium.

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