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Murine models of Aspergillosis: Role of collectins in host defense.

Authors
  • Singh, Mamta
  • Mahajan, Lakshna
  • Chaudhary, Neelkamal
  • Kaur, Savneet
  • Madan, Taruna
  • Sarma, P Usha
Type
Published Article
Journal
Indian journal of experimental biology
Publication Date
Nov 01, 2015
Volume
53
Issue
11
Pages
691–700
Identifiers
PMID: 26669011
Source
Medline
Language
English
License
Unknown

Abstract

Aspergillus fumigatus, a ubiquitous fungus, causes a wide spectrum of clinical conditions ranging from allergic to invasive aspergillosis depending upon the hosts' immune status. Several animal models have been generated to mimic the human clinical conditions in allergic and invasive aspergillosis. The onset, duration and severity of the disease developed in models varied depending on the animal strain/fungal isolate, quantity and mode of administration of fungal antigens/spores, duration of the treatment, and type of immunosuppressive agent used. These models provide insight into host and pathogen factors and prove to be useful for evaluation of diagnostic markers and effective therapies. A series of studies established the protective role of collectins in murine models of Allergic Bronchopulmonary Aspergillosis and Invasive Pulmonary Aspergillosis. Collectins, namely surfactant protein A (SP-A), surfactant protein D (SP-D) and mannan binding lectin (MBL), are pattern recognition molecules regulating both innate and adaptive immune response against pathogens. In the present review, we discussed various murine models of allergic and invasive aspergillosis and the role of collectins in host defense against aspergillosis.

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