Murine model: maternal administration of stem cells for prevention of prematurity

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Murine model: maternal administration of stem cells for prevention of prematurity

Type
Preprint
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.ajog.2014.12.032
Keywords
License
Unknown

Abstract

Using a mouse model of intrauterine inflammation, we have demonstrated that exposure to inflammation induces preterm birth and perinatal brain injury. Mesenchymal stem cells (MSCs) have been shown to exhibit immunomodulatory effects in many inflammatory conditions. We hypothesized that treatment with human adipose tissue-derived MSCs may decrease the rate of preterm birth and perinatal brain injury through changes in antiinflammatory and regulatory milieu.

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