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Murine model: maternal administration of stem cells for prevention of prematurity.

Authors
  • Lei, Jun1
  • Firdaus, Wance1
  • Rosenzweig, Jason M1
  • Alrebh, Shorouq1
  • Bakhshwin, Ahmed1
  • Borbiev, Talaibek1
  • Fatemi, Ali2
  • Blakemore, Karin1
  • Johnston, Michael V2
  • Burd, Irina3
  • 1 Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
  • 2 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD; The Kennedy Krieger Institute, Baltimore, MD.
  • 3 Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD; The Kennedy Krieger Institute, Baltimore, MD. Electronic address: [email protected]
Type
Published Article
Journal
American journal of obstetrics and gynecology
Publication Date
May 01, 2015
Volume
212
Issue
5
Identifiers
DOI: 10.1016/j.ajog.2014.12.032
PMID: 25555657
Source
Medline
Keywords
License
Unknown

Abstract

Maternally administered MSCs appear to modulate maternal and fetal immune response to intrauterine inflammation in the model and decrease preterm birth, perinatal brain injury, and motor deficits in offspring mice.

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