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Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways.

Authors
  • Nitta, Takashi
  • Kim, Jae-Sung
  • Mohuczy, Dagmara
  • Behrns, Kevin E
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2008
Volume
48
Issue
3
Pages
909–919
Identifiers
DOI: 10.1002/hep.22397
PMID: 18712785
Source
Medline
License
Unknown

Abstract

CLDH have increased vimentin and type 1 collagen expression and morphologic features consistent with EMT. In addition, compared to NLDH, the cellular signaling phenotype of CLDH changes from a MAPK-independent pathway to a MAPK-dependent cell survival pathway. These findings may have clinical implications for chemoprevention of hepatocellular carcinoma in the cirrhotic liver.

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