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In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth.

  • Hardwick, Laura JA
  • Davies, Benjamin P
  • Pensa, Sara
  • Burge-Rogers, Maedee
  • Davies, Claire
  • Baptista, André Figueiredo
  • Knott, Robert
  • S McCrone, Ian
  • Po, Eleonora
  • Strugnell, Benjamin W
  • Waine, Katie
  • Wood, Paul
  • Khaled, Walid T
  • Summers, Huw D
  • Rees, Paul
  • Wills, John W
  • Hughes, Katherine
Publication Date
Apr 02, 2024
Apollo - University of Cambridge Repository
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Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the expression of phosphorylated STAT3 (pSTAT3) in the mouse and cow around the day of birth. We present localised colocation analysis, applicable to other mammary studies requiring identification of spatially congregated events. We demonstrate that pSTAT3-positive events are multifocally clustered in a non-random and statistically significant fashion. Arginase-1 expressing cells, consistent with macrophages, exhibit distinct clustering within the periparturient mammary gland. These findings represent a new facet of mammary STAT3 biology, and point to the presence of mammary sub-microenvironments. / LJAH was funded by a Peterhouse Research Fellowship. BPD is funded by an Anatomical Society PhD Studentship awarded to KH. This research was funded by a grant awarded to KH by the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund (NHF_2016_03_KH).

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