Affordable Access

Access to the full text

Mupirocin: applications and production

Authors
  • Tucaliuc, Alexandra1
  • Blaga, Alexandra Cristina1
  • Galaction, Anca Irina2
  • Cascaval, Dan1
  • 1 “Gheorghe Asachi” Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, Iasi, Romania , Iasi (Romania)
  • 2 “Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Iasi, Romania , Iasi (Romania)
Type
Published Article
Journal
Biotechnology Letters
Publisher
Springer-Verlag
Publication Date
Mar 29, 2019
Volume
41
Issue
4-5
Pages
495–502
Identifiers
DOI: 10.1007/s10529-019-02670-w
Source
Springer Nature
Keywords
License
Yellow

Abstract

Mupirocin is an antibiotic from monocarboxylic acid class used as antibacterial agent against methicillin-resistant Staphylococcus aureus (MRSA) and can be obtained as a mixture of four pseudomonic acids by Pseudomonas fluorescens biosynthesis. Nowadays improving antibiotics occupies an important place in the pharmaceutical industry as more and more resistant microorganisms are developing. Mupirocin is used to control the MRSA outbreaks, for infections of soft tissue or skin and for nasal decolonization. Due to its wide use without prescription, the microorganism’s resistance to Mupirocin increased from up to 81%, thus becoming imperative its control or improvement. As the biotechnological production of Mupirocin has not been previously reviewed, in the present paper we summarize some consideration on the biochemical process for the production of pseudomonic acids (submerged fermentation and product recovery). Different strains of Pseudomonas, different culture medium and different conditions for the fermentation were analysed related to the antibiotics yield and the product recovery step is analysed in relation to the final purity. However, many challenges have to be overcome in order to obtain pseudomonic acid new versions with better properties related to antibacterial activity.

Report this publication

Statistics

Seen <100 times