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Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells.

Authors
Type
Published Article
Journal
Differentiation
1432-0436
Publisher
Elsevier
Publication Date
Volume
76
Issue
3
Pages
223–231
Identifiers
PMID: 17825086
Source
Medline
License
Unknown

Abstract

Identification of mesenchymal stem cells (MSCs) derived from alternative sources has provided an exciting prospect for intensive investigation. This work focused on characterizing a new source of MSCs from stromal cells from human eye conjunctiva. In this study, after conjunctiva biopsies and culture of stromal segment of this tissue, fibroblast-like (SH2+, SH3+, CD29+, CD44+, CD166+, CD13+) human stromal cells, which can be differentiated toward the osteogenic, adipogenic, chondrogenic, and neurogenic lineages, were obtained. These cells expressed Oct-4, Nanog, Rex-1 genes, and some lineage-specific markers like cardiac actin and Keratin. Taken together, the results indicate that conjunctiva stromal-derived cells are a new source of multipotent MSCs and despite originating from an adult source, they express undifferentiated stem cell markers.

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