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Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets.

Authors
  • Naclerio, George A1, 2
  • Sintim, Herman O1, 2, 3
  • 1 Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.
  • 2 Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
  • 3 Purdue Institute of Inflammation, Immunology & Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Jul 01, 2020
Volume
12
Issue
13
Pages
1253–1279
Identifiers
DOI: 10.4155/fmc-2020-0046
PMID: 32538147
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The rise of antibiotic-resistant infections has been well documented and the need for novel antibiotics cannot be overemphasized. US FDA approved antibiotics target only a small fraction of bacterial cell wall or membrane components, well-validated antimicrobial targets. In this review, we highlight small molecules that inhibit relatively unexplored cell wall and membrane targets. Some of these targets include teichoic acids-related proteins (DltA, LtaS, TarG and TarO), lipid II, Mur family enzymes, components of LPS assembly (MsbA, LptA, LptB and LptD), penicillin-binding protein 2a in methicillin-resistant Staphylococcus aureus, outer membrane protein transport (such as LepB and BamA) and lipoprotein transport components (LspA, LolC, LolD and LolE). Inhibitors of SecA, cell division protein, FtsZ and compounds that kill persister cells via membrane targeting are also covered.

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