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Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.

Authors
  • Edward S Davis
  • Lucia Wille
  • Barry A Chestnut
  • Penny L Sadler
  • Diane C Shakes
  • Andy Golden
Publication Date
Feb 01, 2002
Source
PMC
Keywords
License
Unknown

Abstract

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

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