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Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood

Authors
  • Kuerten, Stefanie
  • Pommerschein, Giovanna
  • Barth, Stefanie K.
  • Hohmann, Christopher
  • Milles, Bianca
  • Sammer, Fabian W.
  • Duffy, Cathrina E.
  • Wunsch, Marie
  • Rovituso, Damiano M.
  • Schroeter, Michael
  • Addicks, Klaus
  • Kaiser, Claudia C.
  • Lehmann, Paul V.1, 2, 3, 4, 5, 4, 6, 7, 8
  • 1 Department of Anatomy and Cell Biology
  • 2 University of Wuerzburg
  • 3 Department of Anatomy I
  • 4 University of Cologne
  • 5 Department of Neurology
  • 6 Department of Pathology
  • 7 Case Western Reserve University
  • 8 Cellular Technology Limited
Type
Published Article
Journal
Clinical Immunology
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Feb 27, 2014
Volume
152
Issue
1-2
Pages
20–24
Identifiers
DOI: 10.1016/j.clim.2014.02.014
Source
Elsevier
Keywords
License
Unknown

Abstract

•CNS-reactive B cells can be detected in the blood of CIS/MS patients by ELISPOT.•CNS-reactive B cells are absent in healthy control subjects.•CNS-reactive B cells are absent in neurological and autoimmune control subjects.•CNS-reactive B cells in the blood possibly indicate B cell-dependent MS.

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