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In multiple sclerosis, oligoclonal bands connect to peripheral B-cell responses.

Authors
  • Bankoti, Jaishree
  • Apeltsin, Leonard
  • Hauser, Stephen L
  • Allen, Simon
  • Albertolle, Matthew E
  • Witkowska, H Ewa
  • von Büdingen, H-Christian
Type
Published Article
Journal
Annals of Neurology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 01, 2014
Volume
75
Issue
2
Pages
266–276
Identifiers
DOI: 10.1002/ana.24088
PMID: 24375699
Source
Medline
License
Unknown

Abstract

Our data provide a high-resolution molecular analysis of OCBs and strongly support the concept that OCBs are not merely the terminal result of a targeted immune response in MS but represent a component of active B cell immunity that is dynamically supported on both sides of the blood-brain barrier.

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