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Multiple roles of arginine/serine-rich splicing factors in RNA processing.

Authors
Type
Published Article
Journal
Biochemical Society Transactions
Publisher
Portland Press
Volume
33
Issue
Pt 3
Pages
443–446
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. In the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.

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