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The Multiple Levels of Mitonuclear Coregulation

Authors
  • Isaac, R. Stefan
  • McShane, Erik
  • Churchman, L. Stirling
Type
Published Article
Journal
Annual Review of Genetics
Publisher
Annual Reviews
Publication Date
Nov 23, 2018
Volume
52
Pages
511–533
Identifiers
DOI: 10.1146/annurev-genet-120417-031709
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Together, the nuclear and mitochondrial genomes encode the oxidative phosphorylation (OXPHOS) complexes that reside in the mitochondrial inner membrane and enable aerobic life. Mitochondria maintain their own genome that is expressed and regulated by factors distinct from their nuclear counterparts. For optimal function, the cell must ensure proper stoichiometric production of OXPHOS subunits by coordinating two physically separated and evolutionarily distinct gene expression systems. Here, we review our current understanding of mitonuclear coregulation primarily at the levels of transcription and translation. Additionally, we discuss other levels of coregulation that may exist but remain largely unexplored, including mRNA modification and stability and posttranslational protein degradation.

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