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Multiple isoelectric forms of bacterial penicillin-binding proteins: artefacts or genuine cellular components?

Authors
Type
Published Article
Journal
The Journal of antimicrobial chemotherapy
Publication Date
Volume
22
Issue
2
Pages
113–118
Identifiers
PMID: 3141341
Source
Medline
License
Unknown

Abstract

Some bacterial penicillin-binding proteins (PBPs) are reported to exist as multiple isoelectric forms. Other PBPs were examined by two-dimensional electrophoresis to establish whether multiple isoelectric forms are widespread amongst PBPs. Bacillus subtilis PBPs 3 and 5 and Escherichia coli PBPs 1b alpha and 1b gamma focussed as discrete spots with no evidence of multiple isoforms. However, E. coli PBPs 1b beta and 4 displayed isoelectric variants. The results are discussed in relation to current models of bacterial peptidoglycan structure.

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