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Multiple focal nodular hyperplasia

Authors
  • Colle, Isabelle1
  • Op de Beeck, Bart2
  • Hoorens, Anne3
  • Hautekeete, Marc1
  • 1 Department of Hepato-Gastroenterology, Academic Hospital, Free University of Brussels (VUB), Laarbeeklaan, 101, B-1090 Brussels, Belgium, BE
  • 2 Department of Radiology, Academic Hospital, Free University of Brussels (VUB), Laarbeeklaan, 101, B-1090 Brussels, Belgium, BE
  • 3 Department of Pathology, Academic Hospital, Free University of Brussels (VUB), Laarbeeklaan, 101, B-1090 Brussels, Belgium, BE
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer-Verlag
Publication Date
Nov 01, 1998
Volume
33
Issue
6
Pages
904–908
Identifiers
DOI: 10.1007/s005350050198
Source
Springer Nature
Keywords
License
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Abstract

Focal nodular hyperplasia (FNH) is a benign lesion of the liver which usually presents with one or two localizations. We report a patient with history of resection of a biliary cyst, and who had been taking oral contraceptives for the past 18 years, who had multiple localizations of FNH (more than 30 lesions). The largest lesion measured 10.5 × 11 × 12 cm. The imaging characteristics of our patient were atypical. A central scar could be demonstrated only in the largest lesion, in an eccentric location. In the other lesions, no scar formations could be detected. Futhermore, imaging characteristics suggested that several of the lesions contained fat. This was confirmed by biopsy. The patient had an associated inflammatory syndrome which could not be otherwise explained. The patient was advised to stop taking the oral contraceptives. Follow-up after 2 years showed that the lesions were unchanged; the inflammatory syndrome persisted. Multiple localizations of FNH are very rare. Sometimes they are associated with malformations in other organs (vascular malformations and neoplasia, mostly of the brain). Often they occur as isolated cases, however. Usualy their prognosis seems to be good.

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