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Multiple Cutaneous Melanomas and Clinically Atypical Moles in a Patient With a Novel Germline BAP1 Mutation.

Authors
  • Gerami, Pedram1
  • Yélamos, Oriol2
  • Lee, Christina Y2
  • Obregon, Roxana2
  • Yazdan, Pedram2
  • Sholl, Lauren M2
  • Guitart, Gerta E2
  • Njauw, Ching-Ni3
  • Tsao, Hensin3
  • 1 Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois2Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • 2 Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
  • 3 Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston4Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston.
Type
Published Article
Journal
JAMA dermatology
Publication Date
Nov 01, 2015
Volume
151
Issue
11
Pages
1235–1239
Identifiers
DOI: 10.1001/jamadermatol.2015.1701
PMID: 26154183
Source
Medline
License
Unknown

Abstract

To our knowledge, this is the first report of a patient with multiple melanomas, dysplastic nevus syndrome, and an inactivating germline BAP1 mutation. The coexistence of dysplastic nevus syndrome and a BAP1 germline mutation extends the spectrum of the BAP1 tumor predisposition syndrome and may confer a greater risk for cutaneous melanomas.

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