Affordable Access

Access to the full text

Multiple anthelmintic resistance at a goat farm in Slovakia

Authors
  • Babják, M.1
  • Königová, A.1
  • Várady, M.1
  • 1 Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 , (Slovakia)
Type
Published Article
Journal
Helminthologia
Publisher
Sciendo
Publication Date
Jun 08, 2021
Volume
58
Issue
2
Pages
173–178
Identifiers
DOI: 10.2478/helm-2021-0014
Source
De Gruyter
Keywords
License
Green

Abstract

Cases of parasite resistance to the main classes of anthelmintics are increasingly reported from small ruminants at farms in Europe. We visited a goat farm in Slovakia in November 2019 with suspected parasite problems that reduced productivity and performed an in vivo faecal egg count reduction test (FECRT) and an in vitro larval development test (LDT) for all three main classes of anthelmintics. The lowest efficacy (60 %) detected by FECRT was for ivermectin (IVM). Benzimidazole (BZ) efficacy ranged between 80.3 and 86.5 %, and levamisole (LEV) efficacy was 94 %. The results from the in vivo FECRT test were confirmed by the in vitro LDT. Minimum inhibitory concentration (MIC) 173.6 ng/ml for IVM several times exceeded the recommended threshold of 21.6 ng/ml. Mean LD50 for BZ was equal to the threshold concentration, but the other threshold criteria indicated a low level of resistance in the population. The LDT did not indicate the presence of resistance only for LEV. The MIC 1.0 μg/ml for LEV was evaluated as susceptible with respect to species composition. Teladorsagia was the dominant genus after treatment with BZ, IVM, and LEV. Haemonchus contortus was identifi ed after treatment with BZ and LEV.

Report this publication

Statistics

Seen <100 times