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Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.

Authors
  • Poliakov, Eugenia
  • Strunnikova, Natalya V
  • Jiang, Jian-kang
  • Martinez, Bianca
  • Parikh, Toral
  • Lakkaraju, Aparna
  • Thomas, Craig
  • Brooks, Brian P
  • Redmond, T Michael
Type
Published Article
Journal
Molecular vision
Publication Date
Jan 01, 2014
Volume
20
Pages
285–300
Identifiers
PMID: 24644403
Source
Medline
License
Unknown

Abstract

We used a modified ARPE-19 cell model in which melanization was elicited as a response to chronic accumulation of A2E. We found that although A2E treatment led, as has been previously reported, to modest lysosomal alkalinization and lysosomal impairment of ARPE-19 cells, a potential homeostatic mechanism may involve production of a special type of lysosomes containing melanin.

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