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The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

Authors
  • Ibanez, Agustin1, 2, 3, 4, 5
  • Yokoyama, Jennifer S.1, 2, 6, 7
  • Possin, Katherine L.1, 2, 6
  • Matallana, Diana8, 9, 10
  • Lopera, Francisco11
  • Nitrini, Ricardo12
  • Takada, Leonel T.12
  • Custodio, Nilton13
  • Sosa Ortiz, Ana Luisa14
  • Avila-Funes, José Alberto15, 16
  • Behrens, Maria Isabel17, 18, 19, 20
  • Slachevsky, Andrea20, 21, 22, 23, 24
  • Myers, Richard M.25
  • Cochran, J. Nicholas25
  • Brusco, Luis Ignacio26, 27
  • Bruno, Martin A.4, 28
  • Brucki, Sonia M. D.12, 29
  • Pina-Escudero, Stefanie Danielle1, 2, 6
  • Okada de Oliveira, Maira1, 2, 12, 29
  • Donnelly Kehoe, Patricio4, 30
  • And 15 more
  • 1 The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA , (United States)
  • 2 The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin , (Ireland)
  • 3 Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires , (Argentina)
  • 4 National Scientific and Technical Research Council (CONICET), Buenos Aires , (Argentina)
  • 5 School of Psychology, Center for Social and Cognitive Neuroscience, Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Adolfo Ibanez University, Santiago , (Chile)
  • 6 Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA , (United States)
  • 7 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA , (United States)
  • 8 Psychiatry Department, School of Medicine, Aging Institute, Pontificia Universidad Javeriana, Bogotá , (Colombia)
  • 9 Memory and Cognition Clinic, Intellectus, Hospital Universitario San Ignacio, Bogotá , (Colombia)
  • 10 Mental Health Unit, Hospital Universitario Santa Fe de Bogotá, Bogotá , (Colombia)
  • 11 Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín , (Colombia)
  • 12 Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo , (Brazil)
  • 13 Unit Cognitive Impairment and Dementia Prevention, Cognitive Neurology Center, Peruvian Institute of Neurosciences, Lima
  • 14 Instituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico , (Mexico)
  • 15 Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico , (Mexico)
  • 16 Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux , (France)
  • 17 Centro de Investigación Clínica Avanzada, Hospital Clínico, Facultad de Medicina Universidad de Chile, Santiago , (Chile)
  • 18 Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago , (Chile)
  • 19 Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Santiago , (Chile)
  • 20 Clínica Alemana Santiago, Universidad del Desarrollo, Santiago , (Chile)
  • 21 Geroscience Center for Brain Health and Metabolism (GERO), Santiago , (Chile)
  • 22 Neuropsychology and Clinical Neuroscience Laboratory, Physiopathology Department, Institute of Biomedical Sciences, Neuroscience and East Neuroscience, Santiago , (Chile)
  • 23 Faculty of Medicine, University of Chile, Santiago , (Chile)
  • 24 Memory and Neuropsychiatric Clinic (CMYN) Neurology Department, Faculty of Medicine, Hospital del Salvador, University of Chile, Santiago , (Chile)
  • 25 Hudson Alpha Institute for Biotechnology, Huntsville, AL , (United States)
  • 26 Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires , (Argentina)
  • 27 ALZAR – Alzheimer, Buenos Aires , (Argentina)
  • 28 Facultad Ciencias Médicas, Instituto Ciencias Biomédicas, Universidad Católica de Cuyo, San Juan , (Argentina)
  • 29 Hospital Santa Marcelina, São Paulo, São Paulo , (Brazil)
  • 30 Multimedia Signal Processing Group - Neuroimage Division, French-Argentine International Center for Information and Systems Sciences, Rosario , (Argentina)
  • 31 Faculty of Education, National University of Cuyo, Mendoza , (Argentina)
  • 32 Universidad del Valle, Cali , (Colombia)
  • 33 Ph.D. Program in Neuroscience, Department of Psychiatry, Physiology, Pontificia Universidad Javeriana, Bogotá , (Colombia)
  • 34 Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires , (Argentina)
  • 35 Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA , (United States)
Type
Published Article
Journal
Frontiers in Neurology
Publisher
Frontiers Media SA
Publication Date
Mar 11, 2021
Volume
12
Identifiers
DOI: 10.3389/fneur.2021.631722
Source
Frontiers
Keywords
Disciplines
  • Neurology
  • Review
License
Green

Abstract

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.

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