Affordable Access

Multi-omics Signatures and Translational Potential to Improve Thyroid Cancer Patient Outcome

Authors
  • boufraqech, myriem
  • nilubol, naris
Publication Date
Dec 10, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Recent advances in high-throughput molecular and multi-omics technologies have improved our understanding of the molecular changes associated with thyroid cancer initiation and progression. The translation into clinical use based on molecular profiling of thyroid tumors has allowed a significant improvement in patient risk stratification and in the identification of targeted therapies, and thereby better personalized disease management and outcome. This review compiles the following: (1) the major molecular alterations of the genome, epigenome, transcriptome, proteome, and metabolome found in all subtypes of thyroid cancer, thus demonstrating the complexity of these tumors and (2) the great translational potential of multi-omics studies to improve patient outcome.

Report this publication

Statistics

Seen <100 times