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Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging

  • Gennaro, Nicolo
  • Marrari, Andrea
  • Renne, Salvatore Lorenzo
  • Cananzi, Ferdinando Carlo Maria
  • Quagliuolo, Vittorio Lorenzo
  • Di Brina, Lucia
  • Scorsetti, Marta
  • Pepe, Giovanna
  • Chiti, Arturo
  • Santoro, Armando
  • Balzarini, Luca
  • Politi, Letterio S.
  • Bertuzzi, Alexia Francesca
Publication Date
Aug 01, 2020
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Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.

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