Affordable Access

deepdyve-link
Publisher Website

Multimodal sensory integration in single cerebellar granule cells in vivo.

Authors
  • Ishikawa, Taro1, 2
  • Shimuta, Misa1, 2
  • Häusser, Michael1
  • 1 Wolfson Institute for Biomedical Research, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. , (United Kingdom)
  • 2 Department of Pharmacology, Jikei University School of Medicine, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
eLife
Publisher
"eLife Sciences Organisation, Ltd."
Publication Date
Dec 29, 2015
Volume
4
Identifiers
DOI: 10.7554/eLife.12916
PMID: 26714108
Source
Medline
Keywords
License
Unknown

Abstract

The mammalian cerebellum is a highly multimodal structure, receiving inputs from multiple sensory modalities and integrating them during complex sensorimotor coordination tasks. Previously, using cell-type-specific anatomical projection mapping, it was shown that multimodal pathways converge onto individual cerebellar granule cells (Huang et al., 2013). Here we directly measure synaptic currents using in vivo patch-clamp recordings and confirm that a subset of single granule cells receive convergent functional multimodal (somatosensory, auditory, and visual) inputs via separate mossy fibers. Furthermore, we show that the integration of multimodal signals by granule cells can enhance action potential output. These recordings directly demonstrate functional convergence of multimodal signals onto single granule cells.

Report this publication

Statistics

Seen <100 times