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Multimodal noninvasive and invasive imaging of extracranial venous abnormalities indicative of CCSVI: results of the PREMiSe pilot study.

Authors
  • Zivadinov, Robert
  • Karmon, Yuval
  • Dolic, Kresimir
  • Hagemeier, Jesper
  • Marr, Karen
  • Valnarov, Vesela
  • Kennedy, Cheryl L
  • Hojnacki, David
  • Carl, Ellen M
  • Hopkins, L Nelson
  • Levy, Elad I
  • Weinstock-Guttman, Bianca
  • Siddiqui, Adnan H
Type
Published Article
Journal
BMC Neurology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2013
Volume
13
Pages
151–151
Identifiers
DOI: 10.1186/1471-2377-13-151
PMID: 24139135
Source
Medline
License
Unknown

Abstract

Noninvasive DS screening for the detection of venous anomalies indicative of CCSVI may be a reliable approach for identifying patients eligible for further multimodal invasive imaging testing of the IJVs. However, the noninvasive screening methods were inadequate to depict the total amount of azygos vein/VVs anomalies identified with invasive testing. This pilot study, with limited sample size, shows that both a non-invasive and invasive multimodal imaging diagnostic approach should be recommended to depict a range of extracranial venous anomalies indicative of CCSVI. However, lack of invasive testing on the study subjects whose results were negative on the DS screening and of healthy controls, limits further generalizibility of our findings. In addition, the findings from the 2 invasive techniques confirmed the existence of severe extracranial venous anomalies that significantly impaired normal blood outflow from the brain in this group of MS patients.

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