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Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease.

Authors
  • Gargouri, Fatma1, 2
  • Gallea, Cécile1, 2, 3
  • Mongin, Marie1, 2, 3, 4
  • Pyatigorskaya, Nadya1, 2, 3, 5
  • Valabregue, Romain1, 2
  • Ewenczyk, Claire2, 3, 4
  • Sarazin, Marie6, 7
  • Yahia-Cherif, Lydia1, 2
  • Vidailhet, Marie2, 3, 4
  • Lehéricy, Stéphane1, 2, 3, 4
  • 1 Brain and Spine Institute - ICM, Center for NeuroImaging Research - CENIR, Paris, France. , (France)
  • 2 Sorbonne Université, University Pierre and Marie Curie Paris 06, Inserm U1127, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7225, Paris, France. , (France)
  • 3 Brain and Spine Institute (ICM), Team Movement Investigation and Therapeutics, Paris, France. , (France)
  • 4 Department of Neurology, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France. , (France)
  • 5 Department of Neuroradiology, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France. , (France)
  • 6 Department of Neurology, Memory and Language, Paris Descartes University, Sorbonne Paris Cité, Sainte Anne Hospital, Paris, France. , (France)
  • 7 Research unit 1023 Inserm/Commissariat à l'Energie Atomique (CEA)/University Paris, In vivo Molecular Imaging Laboratory (IMIV).
Type
Published Article
Journal
Movement Disorders
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2019
Volume
34
Issue
4
Pages
516–525
Identifiers
DOI: 10.1002/mds.27561
PMID: 30536444
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1-2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4). We investigated changes in basal forebrain and their role in cognitive deficits in PD. We studied 52 nondemented patients with PD (Hoehn & Yahr 1-2) and 25 age-matched healthy controls using diffusion and resting state functional MRI. PD patients had a loss of structural integrity within the Ch1-2 and Ch3-4 nuclei of the basal forebrain as well as in the fornix. Tractography showed that the probability of anatomical connection was decreased in PD between Ch3-4 and the associative prefrontal cortex, occipital cortex, and peri-insular regions. There was a reduction in functional connectivity between Ch1-2 and the bilateral hippocampi and parahippocampal gyri, the left middle and superior temporal gyri, and the left fusiform gyrus and between Ch3-4 and the right inferior frontal gyrus and the right and left thalamus. In Ch1-2, loss of structural integrity and connectivity correlated with scores at the memory tests, whereas changes in Ch3-4 correlated with scores of global cognition and executive functions. This study highlights the association between deficits of different cholinergic nuclei of the basal forebrain and the extent of cognitive impairments in nondemented PD patients. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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