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Multiloci stereotactic transplantation of autologous adrenal medullary tissue to the putamen and caudatum in Parkinson's disease. Technical note.

Authors
  • Schvarcz, J R1
  • Devoto, M
  • Meiss, R
  • Torrieri, A
  • Genero, M
  • Armando, I
  • 1 Department of Neurosurgery, School of Medicine, University of Buenos Aires, Argentina. , (Argentina)
Type
Published Article
Journal
Stereotactic and functional neurosurgery
Publication Date
Jan 01, 1990
Volume
54-55
Pages
277–281
Identifiers
PMID: 2080342
Source
Medline
License
Unknown

Abstract

Adrenal to striatum transplants may be effective, but many technical issues are still debated. A procedure whereby a number of grafts were stereotactically placed at the putamen and caudatum is reported. It enables grafting deep nuclei, such as the putamen, the most denervated structure in Parkinson's disease, and allows a widespread spatial distribution of multiple grafts within these huge targets, conceivably enhancing the local release of neurotransmitters at the site or in the vicinity of the denervated receptors. It also enables the use of a sizeable volume of tissue, presumably a crucial but as yet unknown factor. Although preliminary, the present data seem to warrant further clinical trials.

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