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Multi-layered genome defences in bacteria.

Authors
  • Agapov, Aleksei
  • Baker, Kate S
  • Bedekar, Paritosh
  • Bhatia, Rama P
  • Blower, Tim R
  • Brockhurst, Michael A
  • Brown, Cooper
  • Chong, Charlotte E
  • Fothergill, Joanne L
  • Graham, Shirley
  • Hall, James Pj
  • Maestri, Alice
  • McQuarrie, Stuart
  • Olina, Anna
  • Pagliara, Stefano
  • Recker, Mario
  • Richmond, Anna
  • Shaw, Steven J
  • Szczelkun, Mark D
  • Taylor, Tiffany B
  • And 5 more
Publication Date
Feb 07, 2024
Source
Apollo - University of Cambridge Repository
Keywords
Language
English
License
Green
External links

Abstract

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

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