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Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound

Authors
  • Khan, Atta ur Rehman1
  • Huang, Kai2
  • Khalaji, Mina Shahriari3
  • Yu, Fan1
  • Xie, Xianrui1
  • Zhu, Tonghe4
  • Morsi, Yosry5
  • Jinzhong, Zhao2
  • Mo, Xiumei1
  • 1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China
  • 2 Department of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, 200233, PR China
  • 3 Microbiological Engineering and Industrial Biotechnology Group, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China
  • 4 Multidisciplinary Centre for Advanced Materials of Shanghai University of Engineering Science, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, No. 333 Longteng Road, Shanghai, 201620, PR China
  • 5 Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Boroondara, VIC, 3122, Australia
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Feb 15, 2021
Volume
6
Issue
9
Pages
2783–2800
Identifiers
DOI: 10.1016/j.bioactmat.2021.01.040
PMID: 33665509
PMCID: PMC7900605
Source
PubMed Central
Keywords
License
Unknown

Abstract

• A modified loading strategy was employed for dual bioactive agents through electrospinning. • The nanofibers sustainedly released the two bioactive agents. • The fabricated bioactive membranes turned out to be biocompatible, antioxidant and antibacterial. • The proposed bioactive membranes have posesses the potential of healing diabetic wounds.

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