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The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

Authors
  • Zhou, Wenjia1
  • Chen, Lu1
  • Li, Chao2
  • Huang, Rui3
  • Guo, Mian2
  • Ning, Shangwei4
  • Ji, Jingjing1
  • Guo, Xiaorong1
  • Lou, Ge1
  • Jia, Xinqi1
  • Zhao, Junjie1
  • Luo, Feng1
  • Li, Chunlong1
  • Qu, Zhaowei5
  • Yu, Shan1
  • Tai, Sheng1
  • 1 The Second Affiliated Hospital of Harbin Medical University, No. 246 XueFu Avenue, Harbin, 150086, People’s Republic of China , Harbin (China)
  • 2 The Second Affiliated Hospital of Harbin Medical University, Harbin, China , Harbin (China)
  • 3 The second Affiliated Hospital of Harbin Medical University, Harbin, China , Harbin (China)
  • 4 Harbin Medical University, Harbin, China , Harbin (China)
  • 5 Harbin Medical University Cancer Hospital, Harbin, China , Harbin (China)
Type
Published Article
Journal
Cancer Cell International
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 05, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12935-020-1126-1
Source
Springer Nature
Keywords
License
Green

Abstract

Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biological functional diversity and complexity in protein regulatory networks. Scientific studies have revealed the emerging functions and regulatory roles of lncRNAs in PC behaviors. It is worth noting that some in-depth studies have revealed that lncRNAs are significantly associated with the initiation and progression of PC. As lncRNAs have good properties for both diagnostic and prognostic prediction due to their translation potential, we herein address the current understanding of the multifaceted roles of lncRNAs as regulators in the molecular mechanism of PC. We also discuss the possibility of using lncRNAs as survival biomarkers and their contributions to the development of targeted therapies based on the literature. The present review, based on what we know about current research findings, may help us better understand the roles of lncRNAs in PC.

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