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The multifaceted role of pirfenidone and its novel targets

Authors
  • Macías-Barragán, José1
  • Sandoval-Rodríguez, Ana1
  • Navarro-Partida, Jose1
  • Armendáriz-Borunda, Juan1, 2
  • 1 University of Guadalajara, Institute for Molecular Biology and Gene Therapy, Department of Molecular Biology and Genomics, Guadalajara, Mexico , Guadalajara (Mexico)
  • 2 O.P.D. Hospital Civil de Guadalajara, Guadalajara, Mexico , Guadalajara (Mexico)
Type
Published Article
Journal
Fibrogenesis & Tissue Repair
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 01, 2010
Volume
3
Issue
1
Identifiers
DOI: 10.1186/1755-1536-3-16
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundPirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnormal fibrous wound-healing process; consequently, tissue repair and tissue regeneration-regulating mechanisms are altered.ObjectiveTo investigate the usefulness of PFD as an antifibrotic agent in clinical and experimental models of fibrotic disease.ConclusionsThere is a growing understanding of the molecular effects of PFD on the wound healing mechanism, leading to novel approaches for the management of fibrosis in lung, liver and renal tissues. Although the optimum treatment for fibrosis remains undefined, it is possible that combined therapeutic regimens that include this wide-application molecule, pirfenidone, could offer a useful treatment for fibrotic disease.

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