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A multifaceted role for MOF histone modifying factor in genome maintenance.

Authors
  • Mujoo, Kalpana1
  • Hunt, Clayton R1
  • Horikoshi, Nobuo1
  • Pandita, Tej K2
  • 1 Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States. , (United States)
  • 2 Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Mechanisms of ageing and development
Publication Date
Jan 01, 2017
Volume
161
Issue
Pt A
Pages
177–180
Identifiers
DOI: 10.1016/j.mad.2016.03.012
PMID: 27038808
Source
Medline
Keywords
License
Unknown

Abstract

MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In humans, however, the ortholog of Drosophila MOF has been shown to interact with a range of proteins that extend its potential significance well beyond transcription. For example, recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. Thus, directly or indirectly, MOF may be involved in a wide range of cellular functions. This review will focus on the contribution of MOF to cellular DNA repair and new results that are beginning to examine the in vivo physiological role of MOF.

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