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Multidrug resistance-reversal effects of resin glycosides from Dichondra repens.

Authors
  • Song, Wei-Bin
  • Wang, Wen-Qiong
  • Zhang, Shu-Wei
  • Xuan, Li-Jiang
Type
Published Article
Journal
Bioorganic & medicinal chemistry letters
Publication Date
Feb 15, 2015
Volume
25
Issue
4
Pages
795–798
Identifiers
DOI: 10.1016/j.bmcl.2014.12.083
PMID: 25597010
Source
Medline
Keywords
License
Unknown

Abstract

Investigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A-C (1-3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25μM increased the cytotoxicity of vincristine by 1.03-1.78-fold.

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