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Multidrug and extensively drug-resistant tuberculosis from a general practice perspective.

Authors
  • Yashodhara, B M
  • Huat, Choo Beng
  • Naik, Lakshmi Nagappa
  • Umakanth, Shashikiran
  • Hande, Manjunatha
  • Pappachan, Joseph M
Type
Published Article
Journal
Infection and Drug Resistance
Publisher
Dove Medical Press
Publication Date
Jan 01, 2010
Volume
3
Pages
115–122
Identifiers
DOI: 10.2147/IDR.S10743
PMID: 21694900
Source
Medline
Keywords
License
Unknown

Abstract

Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the main causes for development of drug resistance. Directly observed therapy, short-course (DOTS) is the World Health Organization (WHO) strategy for worldwide eradication of tuberculosis, and our country achieved 100% coverage for DOTS through the Revised National Tuberculosis Control Program in 2006. For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy. Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases. This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

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