A multidisciplinary weight loss intervention in obese adolescents with and without sleep-disordered breathing improves cardiometabolic health, whether SDB was normalized or not.

Johanna Roche; Flavia Campos Corgosinho; Laurie Isacco; Karine Scheuermaier; Bruno Pereira; Valérie Gillet; Gustavo A Moreira; Marcia Pradella-Hallinan; Sergio Tufik; Marco Túlio de Mello; Fabienne Mougin; Ana R Dâmaso; David Thivel

doi:10.1016/j.sleep.2020.06.030

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A multidisciplinary weight loss intervention in obese adolescents with and without sleep-disordered breathing improves cardiometabolic health, whether SDB was normalized or not.

Authors

Roche, Johanna¹
Corgosinho, Flavia Campos²
Isacco, Laurie³
Scheuermaier, Karine⁴
Pereira, Bruno⁵
Gillet, Valérie⁶
Moreira, Gustavo A⁷
Pradella-Hallinan, Marcia⁷
Tufik, Sergio⁸
de Mello, Marco Túlio⁹
Mougin, Fabienne³
Dâmaso, Ana R¹⁰
Thivel, David¹¹

¹ EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, CHRU Jean Minjoz, Boulevard Fleming, 25000 Besançon, France; Sleep and Health Medicine Center Ellipse, Besançon, France; Laboratory of the Metabolic Adaptations to Exercise Under Physiological and Pathological Conditions (AME2P), EA3533, Clermont Auvergne University, Clermont-Ferrand, France; Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: [email protected] , (France)
² Universidade Federal de Goiás, Faculdade de Nutrição - Programa de Pos-Graduação em Nutrição, São Paulo, Brazil. , (Brazil)
³ EA3920, Exercise Performance Health Innovation Platform, University of Bourgogne Franche-Comte, CHRU Jean Minjoz, Boulevard Fleming, 25000 Besançon, France. , (France)
⁴ Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. , (South Africa)
⁵ Clermont-Ferrand University Hospital, Biostatistics Unit (DRCI), Clermont-Ferrand, France. , (France)
⁶ Sleep and Health Medicine Center Ellipse, Besançon, France. , (France)
⁷ Universidade Federal de São Paulo, Escola Paulista de Medicina, Programa de Pos-Graduação em Nutrição, São Paulo, Brazil; Universidade Federal de São Paulo, Escola Paulista de Medicina, Departameno de Psicobiologia, São Paulo, Brazil. , (Brazil)
⁸ Universidade Federal de São Paulo, Escola Paulista de Medicina, Departameno de Psicobiologia, São Paulo, Brazil. , (Brazil)
⁹ Universidade Federal de Minas Gerais, Programa de Pós-Graduação em Educação Física, Minas Gerais, Brazil. , (Brazil)
¹⁰ Universidade Federal de São Paulo, Escola Paulista de Medicina, Programa de Pos-Graduação em Nutrição, São Paulo, Brazil. , (Brazil)
¹¹ Laboratory of the Metabolic Adaptations to Exercise Under Physiological and Pathological Conditions (AME2P), EA3533, Clermont Auvergne University, Clermont-Ferrand, France; Auvergne Research Center for Human Nutrition (CRNH), 58 Rue Montalembert, 63009 Clermont-Ferrand, France. , (France)

Type

Published Article

Journal

Sleep medicine

Publication Date

Jun 30, 2020

Volume

75

Pages

225–235

Identifiers

DOI: 10.1016/j.sleep.2020.06.030

PMID: 32861060

Source

Medline

Keywords

Language

English

License

Unknown

Abstract

Pediatric obesity and sleep-disordered breathing (SDB) are strongly associated, and both promote metabolic impairments. However, the effects of a lifestyle intervention on the overall metabolic syndrome (MetS) are unknown. The objectives were i) to evaluate the effects of a lifestyle intervention on cardiometabolic risk (CMR), assessed with a dichotomous (MetS) and a continuous (MetScoreFM) instrument, in obese adolescents with and without SDB and ii) to compare the post-intervention cardiometabolic responses between adolescents with persistent (apnea-hypopnea index; AHI≥2) or normalized-SDB (AHI<2). Seventy-six adolescents with obesity recruited from two specialized institutions underwent a 9-12month diet and exercise intervention. Sleep and SDB (AHI≥2) were studied by polysomnography. Anthropometric parameters, fat mass (FM), glucose, insulin, lipid and leptin profiles, blood pressure (BP), MetScoreFM and MetS were assessed pre- and post-intervention. We performed comparisons between Non-SDB and SDB groups and between Normalized-SDB and Persistent-SDB subgroups. Fifty participants completed the study. Pre-intervention, twenty youth had SDB (40%) with higher insulin concentrations and systolic BP than Non-SDB participants (p < 0.01), for a similar degree of obesity. Post-intervention, MetScoreFM (p < 0.001) and MetS prevalence (p < 0.05) were decreased in both groups. Eleven participants (55%) normalized SDB along with a decrease in insulin concentrations and BP (p < 0.05). Triglycerides, total cholesterol and LDL-cholesterol concentrations (p < 0.01) improved equally in the Normalized and Persistent-SDB subgroups. SDB was associated with lower insulin sensitivity and higher BP but did not affect the lipid profile. A diet and exercise lifestyle intervention is effective in decreasing the CMR whether or not SDB was normalized in obese adolescents. Copyright © 2020 Elsevier B.V. All rights reserved.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 10/16/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/32861060

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