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Multi-copy single-stranded DNA in Escherichia coli.

Authors
  • Xie, Xianxing1
  • Yang, Ruifu1
  • 1 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, PR China. , (China)
Type
Published Article
Journal
Microbiology
Publisher
Microbiology Society
Publication Date
Oct 31, 2017
Identifiers
DOI: 10.1099/mic.0.000563
PMID: 29087272
Source
Medline
License
Unknown

Abstract

Multi-copy single-stranded DNA (msDNA) is composed of covalently bound single-stranded DNA and RNA, and synthesized by retron-encoded reverse transcriptase. msDNA-synthesizing systems are thought to be a recent acquisition by Escherichia coli because, to date, only seven types of msDNA, which differ markedly in their primary nucleotide sequences, have been found in a small subset of E. coli strains. The wide use of E. coli in molecular research means that it is important to understand more about these stable, covalently bound, single-stranded DNA or RNA compounds. The present review provides insights into the molecular biosynthesis, distribution and function of E. coli msDNA to raise awareness about these special molecules.

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