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Multicentric reticulohistiocytosis with elevated cytokine serum levels.

Authors
  • Bennàssar, Antoni
  • Mas, Antoni
  • Guilabert, Antonio
  • Julià, Marc
  • Mascaró-Galy, José Manuel
  • Herrero, Carmen
Type
Published Article
Journal
The Journal of dermatology
Publication Date
Sep 01, 2011
Volume
38
Issue
9
Pages
905–910
Identifiers
DOI: 10.1111/j.1346-8138.2010.01146.x
PMID: 21658110
Source
Medline
License
Unknown

Abstract

Multicentric reticulohistiocytosis (MRH) is an uncommon non-Langerhans cell histiocytosis of unknown etiology. It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis. Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm. In the immunohistochemical analysis these cells stain positively with monocyte/macrophage markers (CD68 and CD45), as well as with certain cytokines (tumor necrosis factor-α, interleukin 1β and interleukin 6). Moreover, recent reports suggest an osteoclastic nature of the infiltrating cells, as they stain strongly with osteoclast tissue lytic markers including tartrate-resistant acid phosphatase and cathepsin K. We report a case of MRH presenting with clinical features of dermatomyositis. Furthermore, the patient showed elevated cytokine serum levels that lowered after therapy.

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