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A multicenter observational study on the clinicopathological features of gastric cancer in young patients

Authors
  • Kono, Yoshiyasu1
  • Kanzaki, Hiromitsu1
  • Tsuzuki, Takao2
  • Takatani, Masahiro2
  • Nasu, Junichirou3
  • Kawai, Daisuke4
  • Takenaka, Ryuta4
  • Tanaka, Takehiro5
  • Iwamuro, Masaya1
  • Kawano, Seiji1
  • Kawahara, Yoshiro6
  • Fujiwara, Toshiyoshi7
  • Okada, Hiroyuki1
  • 1 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Gastroenterology and Hepatology, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan , Okayama (Japan)
  • 2 Japanese Red Cross Society Himeji Hospital, Department of Internal Medicine, Himeji, Japan , Himeji (Japan)
  • 3 Okayama Saiseikai General Hospital, Department of Internal Medicine, Okayama, Japan , Okayama (Japan)
  • 4 Tsuyama Chuo Hospital, Department of Internal Medicine, Tsuyama, Japan , Tsuyama (Japan)
  • 5 Dentistry and Pharmaceutical Sciences, Department of Pathology, Okayama University Graduate School of Medicine, Okayama, Japan , Okayama (Japan)
  • 6 Okayama University Hospital, Department of Endoscopy, Okayama, Japan , Okayama (Japan)
  • 7 Dentistry and Pharmaceutical Sciences, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan , Okayama (Japan)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Oct 29, 2018
Volume
54
Issue
5
Pages
419–426
Identifiers
DOI: 10.1007/s00535-018-1525-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundThe details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients.MethodsFrom January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated.ResultsThe total number of patients was 72. The median age was 36 years, and the ratio of males to females was 1:1. The dominant histological type was undifferentiated type (66/72, 92%). Helicobacter pylori (H. pylori) was positive in 81% (54/67). Although there were some asymptomatic patients in stages I–III, all stage IV patients had some clinical symptoms at the diagnosis. The percentage of stage IV was significantly higher in patients in their 20s than in those in their 30s (75% vs. 25%, P < 0.001). The Kaplan–Meier method showed that the overall survival of patients in their 20s was significantly lower than that of patients in their 30s (P = 0.037).ConclusionsA high rate of H. pylori infection was revealed in young gastric cancer patients. The patients in their 20s had a worse prognosis than those in their 30s. We should consider examining the H. pylori infection status for young patients as well as older patients to identify high-risk populations.

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