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Multicenter evaluation of a semiautomated, standardized assay for detection of hepatitis B virus DNA in blood donations.

Authors
  • Romanò, Luisa
  • Velati, Claudio
  • Baruffi, Lorella
  • Fomiatti, Laura
  • Colucci, Giuseppe
  • Zanetti, Alessandro R
Type
Published Article
Journal
Journal of clinical microbiology
Publication Date
Jun 01, 2005
Volume
43
Issue
6
Pages
2991–2993
Identifiers
PMID: 15956441
Source
Medline
License
Unknown

Abstract

We evaluated the COBAS Ampliscreen hepatitis B virus (HBV) test using standards, seroconversion panels, consecutive donations, and samples from patients with abnormal alanine aminotransferase and chronic hepatitis C. Specificity was 100% and sensitivity was 20 IU/ml. In seroconversion panels, HBV DNA was detected up to 4 to 18 days before HBsAg, suggesting that this assay is useful in shortening the infectious window phase.

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