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Multi-component analysis of urine of dogs with liver diseases by high-performance liquid chromatography.

Authors
  • Abe, Y
  • Kobayashi, E
  • Suzuki, N
  • Kaneko, A
  • Fujie, T
  • Nagata, Y
  • Matsushima, Y
  • Takai, N
  • Watanabe, T
  • Otsubo, O
Type
Published Article
Journal
Journal of chromatography
Publication Date
Jan 16, 1987
Volume
386
Pages
11–17
Identifiers
PMID: 3558599
Source
Medline
License
Unknown

Abstract

Components of the urine of normal dogs and dogs with liver diseases were analysed by high-performance liquid chromatography (HPLC) using a macroreticular anion-exchange resin with UV detection. The dogs with liver diseases were experimentally prepared by either Eck fistula by portal-caval anastomosis, dimethylnitrosamine-induced liver failure or total hepatectomy by operation. Eighteen chromatographic peaks were numbered and the cross-correlation coefficient of the intensities of every pair of peaks was computed. There were high correlations between several pairs of peaks according to the types and degrees of the hepatic failures, whereas no significant correlation was observed for the peak pairs of normal urine samples. The results showed that HPLC analysis of urine is useful in the diagnosis of the physiological state in liver dysfunction.

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