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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Authors
  • Toubal, Amine1, 2, 3
  • Kiaf, Badr1, 2, 3
  • Beaudoin, Lucie1, 2, 3
  • Cagninacci, Lucie1, 2, 3
  • Rhimi, Moez4
  • Fruchet, Blandine1
  • da Silva, Jennifer1
  • Corbett, Alexandra J.5
  • Simoni, Yannick1, 2, 3
  • Lantz, Olivier6
  • Rossjohn, Jamie7, 8, 9
  • McCluskey, James5
  • Lesnik, Philippe10
  • Maguin, Emmanuelle4
  • Lehuen, Agnès1, 2, 3
  • 1 Institut Cochin INSERM, Paris, CNRS F-75014, France , Paris (France)
  • 2 CNRS, Paris, UMR8104, France , Paris (France)
  • 3 Laboratoire d’Excellence INFLAMEX, Sorbonne Paris Cité, Paris, France , Paris (France)
  • 4 INRA Micalis Institute, Jouy-en-Josas, Paris, France , Paris (France)
  • 5 University of Melbourne, Melbourne, VIC, Australia , Melbourne (Australia)
  • 6 INSERM U932, Institut Curie, PSL University, Paris, France , Paris (France)
  • 7 Monash University, Clayton, VIC, 3800, Australia , Clayton (Australia)
  • 8 Monash University, Clayton, VIC, Australia , Clayton (Australia)
  • 9 Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK , Cardiff (United Kingdom)
  • 10 Institute of Cardiometabolism and Nutrition, ICAN, INSERM, Paris, 1166, France , Paris (France)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Jul 24, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-17307-0
Source
Springer Nature
License
Green

Abstract

Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.

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