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Mucosal Immune System of Cattle: All Immune Responses Begin Here.

Authors
  • Chase, Christopher1
  • Kaushik, Radhey S2
  • 1 Department of Veterinary and Biomedical Sciences, South Dakota State University, PO Box 2175, SAR Room 125, North Campus Drive, Brookings, SD 57007, USA. Electronic address: [email protected]
  • 2 Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA.
Type
Published Article
Journal
The Veterinary clinics of North America. Food animal practice
Publication Date
Nov 01, 2019
Volume
35
Issue
3
Pages
431–451
Identifiers
DOI: 10.1016/j.cvfa.2019.08.006
PMID: 31590896
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This article discusses key concepts important for mucosal immunity. The mucosa is the largest immune organ of the body. The mucosal barrier (the tight junctions and the "kill zone") along with the mucosa epithelial cells maintaining an anti-inflammatory state are essential for the mucosal firewall. The microbiome (the microorganisms that are in the gastrointestinal, respiratory, and reproductive tract) is essential for immune development, homeostasis, immune response, and maximizing animal productivity. Mucosal vaccination provides an opportunity to protect animals from most infectious diseases because oral, gastrointestinal, respiratory, and reproductive mucosa are the main portals of entry for infectious disease. Copyright © 2019 Elsevier Inc. All rights reserved.

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