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Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis.

Authors
  • Coffey, Charles S
  • Mulligan, Ryan M
  • Schlosser, Rodney J
Type
Published Article
Journal
American journal of rhinology & allergy
Publication Date
Jan 01, 2009
Volume
23
Issue
6
Pages
571–574
Identifiers
DOI: 10.2500/ajra.2009.23.3412
PMID: 19958603
Source
Medline
License
Unknown

Abstract

Increased expression of NGF may contribute to neural hyperresponsiveness in CRS sinus mucosa, particularly those patients with NP and/or allergies. BDNF expression is decreased in CRS sinus mucosa. Alterations in neurogenic inflammation may contribute to the pathophysiology of CRS and provide alternative therapeutic targets.

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