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Mucormycosis in a patient with low risk myelodysplasia treated with anti-TNF-alpha.

Authors
  • Keijzer, A
  • van der Valk, P
  • Ossenkoppele, G J
  • van de Loosdrecht, A A
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Dec 01, 2006
Volume
91
Issue
12 Suppl
Identifiers
PMID: 17194657
Source
Medline
License
Unknown

Abstract

Accelerated programmed cell death or apoptosis appears to play an important role in the pathogenesis of myelodysplasia. As overexpression of TNF-alpha has been described to induce cell death in myelodysplasia, treatment with anti-TNF-alpha is currently being explored. Caution is needed because of an increased risk of opportunistic infection during anti-TNF-alpha treatment. We here describe a patient who was treated with anti-TNF-alpha for low risk myelodysplasia and died of invasive mucormycosis.

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