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Mucin gene expression in cardiac myxoma.

Authors
  • Chu, P H
  • Jung, S M
  • Yeh, C H
  • Yeh, T S
  • Wang, C L
Type
Published Article
Journal
International journal of clinical practice
Publication Date
Mar 01, 2004
Volume
58
Issue
3
Pages
306–309
Identifiers
PMID: 15117101
Source
Medline
License
Unknown

Abstract

Myxoma is the most common benign neoplasm of the heart. This work is the first to present an unusual left atrium and mitral valve cardiac myxoma which cannot be completely resected. This cardiac myxoma was also associated with abundant mucopolysaccharidic matrix, including mucin. Mucin gene expression is cell- and tissue-specific, with variations during cell differentiation and inflammation, and is altered during carcinogenesis. The expression of mucin genes in cardiac myxoma has never been elucidated previously. Detailed immunohistochemical analysis of MUC1, MUC2 and MUC5AC has been performed in this left atrium and mitral valve myxoma. Notably, the expressions of mucins in cardiac myxoma must be further evaluated.

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